YANELLYFRANCIAIN YANELLYFRANCIAIN Biology Answered Which choice best describes an independent variable in a scientific investigation? An independent variable is the one variable changed and tested by a scientist in a scientific investigation. An independent variable is an educated guess that a scientist makes after observing something interesting. An independent variable is one part of the hypothesis a scientist writes prior to beginning a scientific investigation. An independent variable is the fastest way to measure the success of a scientific investigation.